Rolling Hills High School, CA; U.C.L.A. (B.S. in Biology); NYU School of Medicine Vilcek Institute of Graduate Biomedical Sciences (M.S. & Ph.D. in Biomedical Sciences)

Peer-reviewed publications

 

1.   Kim, C, Lee, HC, Sung, JJ. (2014)  Amyotropic lateral sclerosis-Cell based therapy and novel therapeutic development. Exp Neurobio. 23(3):207-214.

2.   Chiang, WC, Ching, TT, Lee, HC, Mousigian, C, Hsu, AL. (2012) HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity. Cell. 148(1-2):322-334.

3.   Lee, HC, Wondimu, A, Liu, Y, Ma, JSY, Radoja, S, Ladisch, SL. (2012) Gangliosides suppress granule-exocytosis-mediated cytotoxicity in CD8+ T lymphocytes.  J. Immunology. 189(7):3521-3527.

4.   Lee, HC, Zhang, L. (2009) A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation. Protein Pept Lett. 16(6):642-9.

5.   Xin, X, Lan, C, Lee, HC, Zhang, L. (2007) Regulation of the HAP1 gene involves positive actions of histone deacetylases. Biochem Biophys Res Commun. 362(1):120-5.

6.   Lee-Huang, S, Maiorov, V, Huang, PL, Ng, A, Lee, HC, Chang, YT, Kallenbach, N, Huang, PL, Chen, HC. (2005) Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity. Biochemistry. 44(12):4648-55

7.   Hon, T, Lee, HC, Hu, Z, Iyer, VR, Zhang, L. (2005). The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae. Genetics.169(3):1343-52.

8.   Lan, C, Lee, HC, Tang, S, Zhang, L. (2004) A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex. J. Biol Chem. 279(26):27607-12.

9.   Lee, HC, Hon, T, Lan, C, Zhang, L. (2003). Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1. Mol Cell Biol. 23(16):5857-66.

10. Zhu, Y, Lee HC, Zhang, L. (2002). An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells. DNA Cell Biol. 21(4):333-46

11. Lee, HC, Hon, T, Zhang, L. (2002). The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1. J Biol Chem. 277(9):7430-7

12. Hon, T, Lee, HC, Hach, A, Johnson, JL, Craig, EA, Erdjument-Bromage, H, Tempst, P, Zhang, L. (2001). The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1in the absence of heme. Mol Cell Biol. 21(23):7923-32.

13. Hon, T, Hach, A, Lee, HC, Cheng, T, Zhang, L. (2000). Functional analysis of heme regulatory elements of the transcriptional activator Hap1. Biochem Biophys Res Commun. 273(2):584-91.

 

Published book chapters

 

1.   Lee, HC, Hon, T, Zhang, L. (2003) The actions of Hsp90 and Hsp70 molecular chaperones in heme signaling in eukaryotes. In Recent Research Developments in Molecular and Cellular Biology, ed. J Fagan, N Shimizu, JN Davidson, pp. 11-21. Trivandrum, India: Research Signpost

2.   Hon, T, Lee, HC, Zhang, L. (2001) Molecular actions of heme-regulatory proteins in eukaryotes. In Recent Research Developments in Molecular and Cellular Biology, ed. J Fagan, N Shimizu, JN Davidson, pp. 27-39. Trivandrum, India: Research Signpost